PRODUCT MONOGRAPH. PR. Cathflo. ® alteplase, recombinant . cell line into which the cDNA for alteplase has been genetically inserted. Read all of this leaflet carefully before you What Actilyse Cathflo is and what it is used for. 2. Contents of the pack and other information. 1. Drug monographs for CATHFLO ACTIVASE provide an overview of the drug Keeping the vial of Sterile Water for Injection upright, insert the piercing pin of the .
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Potential interactions between Cathflo Activase and laboratory tests have not been studied.
When I leave for the full dwell time I almost always have result. See heparin monograph for suggested dosing regimens during thrombolysis for acute myocardial infarction. Complete dissolution should occur within 3 minutes. Should serious bleeding in a critical location e. Such force inserf cause rupture of the catheter or expulsion of the clot into the circulation.
No other medication should be added to solutions containing alteplase.
Using Cathflo Activase in patients with infected catheters may release a localized infection into the systemic circulation. There are no data on the presence of alteplase in human milk, the effects on the breast-feeding infant, or the effects on milk production. Safety and efficacy have not been established for systemic thrombolysis; various regimens have been used.
However, an increase in INR from 2. Randomized controlled trials have demonstrated beneficial outcomes when fibrinolytic therapy is administered as early as possible after onset of STEMI symptoms e. Caution should be exercised with patients who have any condition for which bleeding constitutes a significant hazard. Preparation of bolus dose: Children weighing 10 cathlfo 29 kg.
Keeping the vial of Sterile Water for Injection upright, insert the piercing pin of the transfer device provided by the manufacturer vertically into the center of the stopper. Use systemic thrombolytics with caution in patients with hemostatic defects due to severe hepatic disease or renal disease associated with oackage failure ctahflo in any patient with significant hepatic dysfunction; the bleeding risk of alteplase may be increased and should be weighed against the anticipated benefits.
The interaction of Cathflo Activase with other drugs has not been formally studied. We have commonly left the Inspect the product before administration for foreign matter and discoloration.
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The link you have selected will take you away from this site to one that is not owned or controlled by Genentech, Inc. Alteplase is indicated for the treatment of acute ischemic stroke, for improving neurological recovery and reducing the incidence of disability; initiate treatment within 3 hours after the onset of stroke symptoms, and after exclusion of intracranial hemorrhage by a cranial computerized tomography CT scan or other diagnostic imaging method sensitive for the presence of hemorrhage.
Agree with leaving cath flow for minutes if doesn’t clear out the first time. Get useful tools to help you ensure and promote patency in your clinical practice.
Limited studies in patients with myocardial infarction and patients with thromboembolic disease indicate that the terminal half-life of alteplase is approximately 45 and 30 minutes, respectively. I had an inservice earlier this year and learned a ton.
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The information contained in this section of the site is intended for U. Pre-treatment with oral anticoagulants is reported to be an independent risk factor for intracranial hemorrhage in thrombolytic-treated patients. Several years ago, our outpatient clinic would leave the Cath-Flo in for up to 24 hours in cas Moderate Green tea has demonstrated antiplatelet paclage fibrinolytic actions in animals.
Bloomington St, Greencastle,IN Major Monitor patients closely and promptly evaluate any signs or symptoms of bleeding if betrixaban and thrombolytic agents are used concomitantly. Dwell times of 0.
General Certain causes of catheter dysfunction should be considered before treatment with Cathflo Activase e. Mix gently by swirling until the contents completely dissolve. If it shows that placement is correct then we get a Md order to proceed.
Bleeding Inwert most frequent adverse reaction associated with all thrombolytics in all approved indications is bleeding. Administer using a polyvinyl chloride bag or glass vial and infusion set. Long-term studies in animals have not been performed to evaluate the carcinogenic potential or the effect on fertility.
Choline Salicylate; Magnesium Salicylate: Slight foaming upon reconstitution may occur; standing undisturbed for several minutes is sufficient to allow dissipation of any large bubbles. After 30 minutes of dwell time, assess catheter function by attempting to aspirate blood. Specific guidelines for dosage adjustments in hepatic impairment are not available; it appears that no dosage adjustments pwckage needed.