Evonik’s EUDRAGIT® polymers enable gastrointestinal tract targeting, along with improved protective, sustained-release and solubility performance. Copolymer, EUDRAGIT L 30 D is the aqueous dispersion of anionic polymers with methacrylic acid as a functional group. Physical properties: It is a. Pellets were coated with Eudragit L 30 D using fluidized bed processor. Different weight gains of acrylic polymer were applied onto the pellets and evaluated.
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The angle of repose was measured using funnel with 6 mm diameter orifice 20 g of pellets were placed in funnel and allowed to fall 4 cm onto a hard level surface. Similarly pellets were also prepared with varying amount of granulating liquid, higher granulating liquid content resulted in harder pellets that could be a factor in delaying dissolution behavior.
Different weight gains of acrylic eudrahit were applied onto the pellets and evaluated o30 in vitro dissolution behavior in 0. The friability eudrait the uncoated pellets was determined by inserting 20 g sample of pellets inside a fluidized bed unit fitted with a Wurster insert. A g of batch of pellets was placed in the fluid bed coater and pre warmed for 10 min prior to the spraying.
EUDRAGIT® L 30 D Spray Suspension Formulation
Following materials were used for the development of multiparticulate system: MatWeb is intended for personal, non-commercial use. Average pellet size was determined by sieve analysis and found to be It is a milky-white liquid of low viscosity with a faint characteristic odor.
Shaker was shaken for 20 min, particles retained on different sieves were collected and average pellets size was determined. Twenty grams of pellets were poured gradually through a funnel into a 50 ml graduated cylinder, tapped 50 times using USP density test apparatus. The focus of the present study was to produce pellets as multi-particulate delivery system, because of its advantages v55 monolithic dosage forms.
Subcoating has been proposed by many scientists [ 4 – 6 ] as a method to improve the acid resistance for enteric coated dosage forms. Processing parameters are given in Table 1.
Evonik EUDRAGIT® L 30 D Copolymer
The results indicated that it is possible to prevent the acidic degradation of sod PAS in upper GI tract which ultimately affect the bioavailability of drug and will help to reduce the dose, by development of multiparticulate system coated with pH dependent polymers using extrusion spheronization technique and fluidized bed processor.
With increase in MCC content, surface of pellets had more plastic euxragit due to accommodate an increased granulating liquid thus they could be easily deformed during spheronization.
Optimized process conditions and parameters are listed in Table 1. The aim of this study was to develop an enteric coated multiparticulate formulation, which ensures the protection of sod PAS in acidic environment and delivers the drug in intestinal region.
Microcrystalline cellulose was used as filler in concentration of The percentage friability was calculated from the pellet weight before and after fluidization [ 8 ]. The carboxylic groups ionize in aqueous media at pH 5. The multiparticulate formulation of sodium para aminosalicylate for oral administration was developed by extrusion spheronization technique.
Coating was performed in fluidized bed coater under conditions as listed in Table 2. Login to see your most recently viewed materials here.
Drug turns brown when comes in contact l0 air due to oxidation of phenolic group in benzene moiety, therefore 0. In preliminary trials, various formulation combinations Table 3 and conditions including spheronization speed, amount of granulating liquid, and spheronization time were investigated to produce spherical and smooth surface pellets Table 2.
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EUDRAGIT® L 30 D-55 Spray Suspension Formulation
A peristalsis pump was used to deliver the coating dispersion to the spray nozzle. Subscribe to Premium Services Searches: All the reagents and solvents used were of analytical grades. Pellets were then transferred from the fluidized bed and the residual powder was removed prior to recording the final weight.
Surface morphology of developed pellets were investigated under scanning electron microscope which revealed a smooth and spherical surface fig. The extrudates was spheronized for 2 min in Fauji Paudal mearumerizer [ 7 ]. The coated pellets were kept in glass dishes and stored in a closed container at ambient temperature. The dispersion was stirred slowly to avoid the production of air bubbles. Subcoating of pellets is done to improve acid resistance of entericcoated dosage forms.
In order to avoid the gastric irritation and degradation of drug in upper gastro intestinal tract, above developed pellets were further coated with enteric polymer.
Media were agitated at rpm and samples were taken at regular intervals, filtered through 0.
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We advise ,30 you only use the original value or one of its raw conversions in your calculations to d555 rounding error. Subscribe to our Newsletter All our latest content delivered to your inbox.
Acrylates Copolymer Information provided by Evonik. Acrylates Copolymer Information eudragig by Evonik Vendors: A magnetic stirrer was used to continually mix the coating dispersion during the coating process to prevent sedimentation. The contents, results, and technical data from this site may not be reproduced either electronically, photographically or substantively without permission from MatWeb, LLC.
The effect of the polymethacrylate copolymer coating system and weight gain applied were evaluated for in vitro release in order to obtain delayed release. Property Data This page displays only the text of a material data sheet.